If you initiate a Lucky 38 Executive Override, the Securitrons will not be hostile to you when you activate the terminal to go into Mr. House's chamber.
PCPlayStation 3Xbox 360 Sometimes Yes Man disappears after killing Mr. House.
PCPlayStation 3Xbox 360 Securitrons may not become hostile or only Jane will.
PlayStation 3Xbox 360 After disabling House the objective does not check off which prevents Yes Man from meeting you outside Lucky 38. (Double check that you have selected the option to permanently disable House from all systems on the same console used to wake him from the chamber)
PlayStation 3Xbox 360 Sometimes you do not need to have the Lucky 38 VIP Keycard or a Science skill of 50 to activate the terminal; it will be automatically be unlocked.
PC Sometimes you will try to access the Penthouse terminal to enter the inner chamber, but it will not trigger. Also sometimes the terminal doesn't open immediately (just beeps) but if you turn away the terminal screen appears wherever you are in the room. It may just require waiting several minutes after using the open command to begin using the terminal.
PlayStation 3 If, after informing Mr. House you're keeping the chip no matter what, you leave the Lucky 38 without killing or disabling him (and even if you killed Victor in the ensuing fight) an unarmed Securitron with Victor's face will chase you around the Strip, punching you. He can't follow you into Strip establishments, but people all around you panic as if he were there.
PlayStation 3 If you have found and picked up the Lucky 38 VIP Keycard before starting this mission, it may not appear in the player's inventory.
Xbox 360 You discover Yes Man after you have killed both Benny and Mr. House, as well as destroyed the Securitron bunker, and you tell Yes Man about your actions (it may not matter if you say anything). A flashing waypoint will lead you to Yes Man once you leave dialogue. You cannot enter a dialogue, but Yes Man tells you he can't wait to get into the mainframe. Completing the quest Wild Card: Side Bets may resolve this bug.
Xbox 360 If you're trying to stay on good terms with all factions until late in the game to get all 4 endings, there is an issue when trying to complete Caesars Legion quest lines. When you go to kill Mr House for Caesar, if you also have the quest from Yes Man to kill Mr House then Caesar see this as hostility towards them. If you've already got the mark of Caesar you won't be able to enter his tent without being attacked no matter how sneaky you are. Killing Yes Man also glitches and doesn't remove his quest from your Pip-Boy.