|For a lore overview, see Radiation.|
Accumulating radiation does not reduce SPECIAL statistics. Rather, it ticks away on the health bar, lowering one's maximum health; therefore, the more radiation one accumulates, the lesser one's health. As in Fallout 3 and Fallout: New Vegas, the maximum number of rads one can take before dying from hit point loss is 1000.
Several perks, such as Lead Belly, Aquaboy, and Rad Resistant are dedicated to reducing the amount of radiation taken, along with a special decontamination arch that can be found around the world and also be built by the player to cleanse them of any radiation for free. Additionally, several pieces of armor can be modified to improve radiation resistance.
Unlike earlier titles, radiation is also weaponized in the game, in the form of Gamma guns, rifles, and traps, as non-player human characters are no longer immune to radiation, and as such, can be killed by it.