When combined with mid to high explosives skill, the pulse grenade makes very short work of any sentry bot, protectron, Mister Handy, or any other drones or turrets. The pulse grenade is one of the most effective anti-robot weapons in the game, next to the pulse gun. When detonated, the pulse grenade will generate an electromagnetic pulse in the form a sphere, damaging anything inside its 35-foot radius.
Unlike in Fallout 3, pulse weapons in Fallout: New Vegas do have an effect on power armored non-player characters and the player. Use extreme caution when using any pulse weapons near friendly power armored non-player characters, or when wearing power armor yourself.