This made the Calculator corrupted and instead of releasing the robots to make the Wasteland safe for humanity, the robots manufactured from Vault 0 used its arsenal and anywhere else that sufficient armament could be found, to exterminate all life, completing the so called "pacification protocol". Humanoid Robots can use most normal human equipment, without any sort of RS-231.5 interface required by most robotics.
The game takes place in 2197 in the American Midwest. The Eastern Brotherhood of Steel is trying to claim territory surrounding Chicago. The Warrior, the player character, is a new recruit to the Brotherhood, tasked to lead a squad of soldiers made up of available initiates.