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|For an overview of grenade models used throughout the Fallout series, see Grenade.|
A magnetically sealed plasma delivery unit, with detonating explosives. Creates a blast of superheated plasma on contact.”— Fallout 2 In-game description
It is not recommended to use them against the Enclave soldiers as their advanced power armor can absorb around 50-80% damage. However, just about everyone and everything else has a low plasma resistance, making this grenade type the most useful late to end game.