Nuka-grenades are crude, yet effective, bombs consisting of a sealed tin can filled with Nuka-Cola Quantum, Abraxo cleaner and turpentine, which react with one another to explode. Around the middle are several strips of tape and the word "RADIATION" or "DANGER" written in black marker.
When thrown, the grenade erupts into a great blue fireball. Its power is bested only by the mini nuke and the bottlecap mine (with perks). Flames and radiation linger for a few seconds after the explosion.
Thrown grenades are affected by physics; they may bounce or roll unexpectedly if not thrown carefully. However, in-game physics can also be used to your advantage, such as throwing grenades through doorways or bouncing them around corners to attack enemies who cannot see you.
Grenades can be targeted in V.A.T.S. and can thus be shot out of the air. Shooting them whilst they are still held by the enemy can detonate them as well. Grenades can be thrown point-blank in V.A.T.S due to the sharply reduced damage taken.
A grenade that has been thrown toward you will show up on your HUD as a red arrow denoting its direction relative to you. Move in the opposite direction as quickly as possible to escape the blast radius.
Holding the fire button down for a longer period of time will increase the strength of the throw. Grenades can be thrown for longer distances than normal through successful V.A.T.S. hits. Grenades cannot be cooked to detonate earlier.
It is also possible to plant a live grenade on a non-player character via reverse-pickpocketing.
Followers don't seem to take the Nuka-grenade's increased explosive radius into consideration when tossing them. This can lead to some nasty limb damage to both the player and their follower.
If you have the Quantum Chemist perk provided by the Broken Steel add-on, you can turn ten regular colas into a single Nuka-Cola Quantum, and since regular Nuka-Colas are much more common and can be found in restocked inventories of some merchants, the perk allows you to create an essentially unlimited supply of these grenades.
The Nuka-grenade should be very carefully used at close ranges. Besides having a risk of dealing massive damage to the player when used incorrectly (just like any other grenade), the radiation levels from a Nuka-grenade explosion can be astoundingly high. It produces a lingering radiation level of 50 rads for 2 seconds that is roughly half the size of the explosion itself.
In the G.E.C.K., the Nuka-grenade is called Nuka cocktail, as its original design was based on a Molotove cocktail, using a Nuka-Cola Quantum as a component. The model for this early design can still be found in Fallout 3's projectiles folder of Meshes.bsa.
If one is thrown on or at Harold he will catch on fire before it explodes.
Cut content The Nuka-grenade's original design as the Nuka cocktail.
Parentheses () denote unique weapon variants, italics denote weapons available through add-ons.
↑The Lone Wanderer: "What can you tell me about Nuka-Cola Cocktails?" "Tell me more about the Nuka Grenade." Sierra Petrovita: "I don't know a whole lot about weapons, but I do know that it's more powerful than the Molotov Cocktail. It explodes in a huge blue flame too! How cool is that?" (Sierra Petrovita's dialogue)
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