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Melissa may refer to:
- Melissa Lewis - a member of the Great Khans and daughter of Chomps Lewis in Fallout: New Vegas.
- Melissa Watkins - an Initiate of the Mojave chapter of the Brotherhood of Steel in Fallout: New Vegas.
- Melissa Bai - an NCR soldier who died during the First Battle of Hoover Dam, mentioned in Fallout: New Vegas.
- Melissa - a survivor of the Great War whom perished in the closet of the Gwinnett Restaurant shortly thereafter, mentioned in Fallout 4.
- Melissa Madison, a pre-War American citizen who was accepted into Vault 114. She is mentioned in Fallout 4.
- Real-life person