As well as being a founding member of long running television show MADtv, Wilson was also the second longest running member of the cast, having starred from the opening episode in 1995 until her departure in 2003. She was credited with creating several popular characters on the show such as Bunifa Latifah Halifah Sharifa Jackson and acclaimed for her impersonating and parodying of Oprah Winfrey.
She has continued to act, host, and perform voice acting roles in film and TV over the years.
