Head to Goodsprings Source, and towards the water trough, you'll see Barton Thorn wandering around the radio tower. Talk to him, and he'll plead for your help to save his girlfriend trapped by geckos. He'll give you clear directions on where to go: head towards the broken radio tower, then turn right. There you should be going up an incline.
There will be broc flowers growing on the slope. Kill all the geckos that come into your path. As you go up, you should see a path forking off towards the right. There is a refrigerator, bed, and some loot (the optional cache). Be careful, however, of the three bear traps.
On your way down after finding no girlfriend, Barton will be right there carrying a pistol, revealing his "clever" ruse to have you clear the geckos out and leaving him with the loot atop the hill. He will then begin firing upon you, to which you can return fire or run away.
The prospector's camp can be reached without exiting the invisible boundary that finalizes character's attributes and skills by maneuvering southward along the clifftops from Victor's shack. This route is useful in reaching the camp while avoiding the geckos guarding the ridge as well.
Because of the geckos spawning in the area, he can sometimes be found already dead before the player can talk to him.
Behind the scenes
The title is a reference to the Coen Brothers movie Barton Fink.