The powerful .44 Magnum round was originally developed for revolvers. Soon adapted for pistols and even rifles, it is a large-bore cartridge delivering a heavy, sizable bullet at very high velocities. Its excellent stopping power and range also result in plenty of recoil and a distinctive muzzle blast, making it a poor choice for users prizing maneuverability and control over sheer firepower. However, it remains well suited for any inhabitant of the wasteland needing a round capable of stopping monsters, human or otherwise.
Both types of .44 FMJ perform identically without affecting the weapon's performance, due to a bug in the Fallout executable that prevents the game from factoring ammo modifiers into the damage calculation.