Forum:Playthrough options??

Hey all

I've just started playing Fallout again after a break and am going to start a new game and trying to decide my tactic. I want to get 100% completion of quests and first decision is do I do main storyline till last quest and the pick up the sideline quests after or go for the sidelines first then main quests.

Next problem is with quest order. Are there some quests other than those I know about which I will list below which will prevent me completing others?

Cant blow up Megaton till got sidequests from there. Cant do shoot them in the head till after dealing with tenpenny.

Cheers for the help

Sticks