Forum:Does Bad Karma prevent you from finishing the Main Quest?

I've been looking at the Wiki Walkthrough for the Main Quest (having completed it several times as a Goody Two-Shoes) and noticed that there doesn't seem to be any Karma Requirements for any of the quests. Dr. Li will trust you to save her in the Taft Tunnel even if you have blown up Megaton. The Brotherhood of Steel, and in particular Sarah Lyons, will not only trust you to come with them to liberate the Jefferson Memorial, they'll offer you membership in the Lyon's Pride, even if you have been killing Regulators and eating their still-warm raw human flesh. Are there any disadvantages at all to Bad Karma other than superficial problems and Three Dog condemning you over the airwaves? -- Webgiant 19:34, December 4, 2010 (UTC)

well multiple people hunting you down, not to mention it seems difficult to play as an evil person, half the time i just play the game in the way that gets me everything i want for my chars advantage, and still have high karma. Toolazytomakeaaccount 09:35, December 9, 2010 (UTC)