Eliminate Mr. Bishop.

Eliminate Mr. Bishop is a side quest in Fallout 2.

Walkthrough
When Roger Westin is faced with the prospect of his death at the hands of the Chosen One, the Councilman offers him a deal: eliminate his employer, John Bishop, for money and information about his objective. Should the player accept, he has to travel to New Reno and find a way to assassinate the head of the Bishops.

The target resides on the second floor of the Shark Club, surrounded by his henchmen. There are four possible approaches to the situation:
 * 1) Blast Bishop apart with your favorite gun and then slaughter everyone and everything that comes in sight and doesn't start running immediately as you exit the Shark Club.
 * 2) Overdose John Bishop on super stimpaks (not too realistic).
 * 3) Sleep with Leslie Anne Bishop, suggest that Bishop have an accident (high traps skill required) and place an explosive trap on his safe. Then watch the fireworks.
 * 4) The fourth is to change the combo on the safe and get Mr. Bishop to fall into his own trap. First, the safe must be trapped. It is trapped by default, but you can rearm it with either dynamite or C4 if you have all ready disarmed it. Once it is trapped, use repair on it, and it should say you changed the password. Head down one level and wait for a while or walk around. After a while, you'll hear an explosion and get the message "You hear a muffled boom upstairs" followed by "Mr. Bishop was hit for 5900 points damage and killed". This method will not turn the Shark Club hostile.

Then, its just a matter of returning to Westin and collecting your reward.